Ed, Drugs Prolong Life, prevent heart attack? We Can’t Stop the development of old drugs

2021/04/01

The researchers looked at a variety of PDE5 inhibitors, and impotence is a blessing in disguise

On March 23, the Swedish Karolinska Institutet team published a paper in the Journal of the American College of Cardiology, the Association of respiratory diseases -- 5 Inhibitors Versus ALPROSTADIL With Survival in Men With Coronary Artery Disease. 2021.


After comparing ALPROSTADIL with a variety of PDE5 inhibitors, Swedish researchers found that if men were treated with coronary artery disease as well as with PDE5 inhibitors for Ed, not only does it lower the risk of a new heart attack, but it also extends life expectancy.

First, Ed (erectile dysfunction) is a common multifactorial disease that affects a large number of men. Older men, in particular, are very common. As for which PDE5 inhibitor, sildenafil, tadalafil, vardenafil, etc. .

The study counted 16,548 men treated with PDE5 inhibitors alone and 1,994 men treated with Alprostadil alone, with an additional 2,116 PDE5 inhibitors combined with alprostadil. During a mean follow-up of 5.8 years, 2261 patients (14%) died in PDE5i group and 521 patients (26%) died in ALPROSTADIL group.

It’s not exactly news that the PDE5 inhibitor works on the heart and everything. After all, sildenafil itself was first developed as a treatment for cardiovascular disease. It was synthesized in 1989 for the treatment of angina pectoris, and entered clinical development in 1991, failing in mid-1993. But in late 1993 it was reintegrated into the ED study because of its powerful flag raising effect. It was approved by the FDA in 1998 to treat ED. Often talk about sildenafil, there are a number of R & D personnel left tears of envy, hope that this error more point on the good.

But not everyone will choose to buy erectile dysfunction drugs, and for privacy reasons, even if they do, they may not tell their doctor. The sheer size of the population suggests that the Swedes have made their choice between science and privacy.


Is it to eat to promote boner medicine can certainly increase life span? Is there a risk?

According to the directions on a drug company’s vardenafil tablets, there is a small chance of adverse reactions such as angina, myocardial infarction, or ventricular tachycardia. So in many countries, including our own, this is a prescription drug, and it has to be administered under the supervision of a doctor.

But the study did not look at women, so it is not clear whether it would actually bring significant economic benefits to drug companies. But at least it is clear that there is still room for further research on PDE5 inhibitors. Mankind has always had a positive attitude towards the cure of disease and the enjoyment of the body and mind.